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FGF and mesoderm formation : ウィキペディア英語版 | FGF and mesoderm formation
Role of FGF Signaling in Mesoderm Formation Mesoderm formation is a complex developmental process involving an intricate network of signaling pathways that coordinate their activities to ensure that a selective group of cells will eventually give rise to mesodermal tissues in the adult organism. FGF contributes to this process not only by promoting mesoderm formation, but also by inhibiting endodermal development. ==Introduction==
During early vertebrate development, the stage is set for the specification of the three germ layers : endoderm, mesoderm and ectoderm,〔(1)〕 which will give rise to the adult organism. The mesoderm will eventually differentiate into numerous tissues including muscles and blood.〔(2)〕 This process requires the precise integration of a variety of signaling pathways such as the transforming growth factor type β (TGFβ), fibroblast growth factor (FGF), bone morphogenetic protein (BMP), and Wnt, to achieve the induction, specification, formation and differentiation of the mesoderm layer within a given time and space.
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